Departmental Bulletin Paper 腸内細菌と疾患 - 宿主を制御する常在細菌叢のバイオロジー
Enterobacteric flora and Diseases - Indigenous microbiota regulate the host health
チョウ ナイ サイキン ト シッカン ヤドヌシ オ セイギョスル ジョウザイ サイキン ノ バイオロジー

野村, 秀明  ,  Hideaki, NOMURA  ,  神戸常盤大学教育イノベーション機構(保健科学部医療検査学科)

Human is not a uni-organism but an integrated multi-organisms with numerous microbiota distributed from skin surface to intraluminal mucosa of the body. The digestive tract, especially, contains totally one billion of bacteria, and the whole of them weighs over 1.5 kilogram. The total amount of enterobacterial DNA is almost hundred times more than that of the host. The enterobacteria form the flora with other indigenous microbiota of virus, fungus, and protozoas. It has been noted that human intestinal microbiota is in static and synergistic relationship with the host. But recent progress of the enterobacterial research with DNA analysis clarified the more dynamic and strong correlation between the flora and the host.Not only digestive diseases but metabolic, immunologic, cancerous, and mental ones can be attributed to the disorder of intestinal microbiota. In this paper, status quo of the microbiota investigation correlating with the diseases is reviewed and the new clinical treatment of probiotics, prebiotics and fecal transplantation are introduced.

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