Investigation of transporter-mediated interaction between cisplatin and silver sulfadiazine in rats
小田, 祐一郎 ,
日髙, 宗明 ,
鈴木, 彰人 ,
おだ, ゆういちろうYuichiro, Oda
九州保健福祉大学研究紀要 = Journal of Kyushu University of Health and Welfare
77 , 2017-03-25
Cisplatin (CDDP) is a platinum complex and is used for treatment of solid tumors. CDDP administeredintravenously is ingested into the cells by copper transporter 1 (CTR1). Silver sulfadiazine (AgSD) is atopical antibiotic that prevent wound infection. Ag is reported to inhibit the mechanism of CTR1. Weexamined transporter-mediated drug-drug interaction using CDDP and AgSD in rats. The serumconcentrations of platinum in blood and in kidney and liver tissues were measured. A blood test wasperformed to observe the interactive effects of CDDP and AgSD. AgSD pretreatment significantlydecreased the concentrations of platinum in blood and in kidney tissue compared to the control. AgSD alsodiminished the CDDP-induced abnormalities of serum creatinine level but did not affect CTR1 expression.In contrast, no significant change was observed in platinum concentration in liver tissue after AgSDpretreatment. However, the level of alanine aminotransferase increased after administration of CDDPwith or without AgSD. These results suggest that CDDP administered intravenously interacts with AgSDapplied to region of wound, in association with changing the platinum concentrations in blood and tissuedistribution. The interactive effects of CDDP may relate to modulate the function of platinum transferringvia CTR1 in the presence of Ag.