Departmental Bulletin Paper Serum levels of soluble CD93 in patients with chronic renal failure

池脇, 信直  ,  園田, 徹  ,  小川, 修  ,  右田, 平八  ,  丹下, 佳洋  ,  イケワキ, ノブナオ  ,  ソノダ, トオル  ,  オガワ, オサム  ,  ミギタ, ヘイハチ  ,  タンゲ, ヨシヒロ  ,  Nobunao, IKEWAKI  ,  Tohru, SONODA  ,  Osamu, OGAWA  ,  Heihachi, MIGITA  ,  Yoshihiro, TANGE

In this clinical study, we examined the serum levels of soluble CD93 (sCD93) in patients with chronic renal failure (CRF) by an originally constructed enzyme-linked immunoassay (EIA) using a CD93 monoclonal antibody (mAb) (mNI-11) established in our laboratories. The serum concentrations of sCD93 in patients with CRF were significantly higher (P < 0.001) than those in normal healthy controls. Furthermore, the serum levels of interleukin-6 (IL-6) were also significantly higher in the patients with CRF (P < 0.05) than in the normal healthy controls. In addition, the serum levels of sCD93 were strongly correlated with the blood urea nitrogen (BUN) (r = 0.797, P < 0.001), serum creatinine (r = 0.784, P < 0.001) and serum cystatin C (r = 0.913, P < 0.001). Taken together, these findings suggest that the serum sCD93 may serve as a new biomarker for analyzing or measuring renal function.

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