Departmental Bulletin Paper 〔研究ノート〕慢性腎臓病発症閉経モデルラットにおける 酸化障害,抗酸化能に対する 食餌アーモンドペースト投与の影響

海老沢, 秀道  ,  渡辺, 睦行  ,  島, 知世  ,  都築, 公子  ,  江草, 信太郎  ,  飯野, 久和

(926)  , pp.28 - 34 , 2017-12-01 , 昭和女子大学近代文化研究所
  The present study was carried out to find out the protective effects on oxidation disorders in menopausal model rats with chronic kidney disease (CKD) of a diet supplemented with almond paste. Nine-week-old female rats were divided into 3 groups: Control, AL, and Intact groups. The rats in the Control group and the rats in the AL group received 360 mg/kg BW of adenine intragastrically for 4 consecutive days so that they would develop CKD. After 7 days of recovery, the 3 groups of rats received ovariectomies (OVX) under anesthesia.  Beginning three days after the OVX, for 8 weeks, the rats were given 13g per day of 20% casein protein diet supplemented with 0% almond paste (for the Control group and the Intact group) or 0.5% almond paste (for AL group). All the rats were killed under anesthesia and their TBARS in liver and kidney, BAP and dROM in serum, and some biochemical parameters in serum and urine were measured and the values of the AL group and the Control group were compared.  Both groups showed 1) no significant differences in body weight changes, organ weights and blood analyses. The AL group showed 2) 22% lower value in serum creatinine concentration, 3) 28.5% higher value in creatinine clearance, 4) significantly higher value of TBARS in the liver. And the two groups showed 5) no significant differences in BAP and d-ROM values.  From the above results, the authors conclude that the almond paste supplemented diet did not have significant influence on the degrees of the lipid peroxidation, the oxidation stress and the anti-oxidation ability of the menopausal model rats with CKD used in this study. On the other hand, it may be possible to improve renal function in menopausal model rats with CKD using a diet supplemented with almond paste.

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