紀要論文 〔研究ノート〕卵巣摘除された慢性腎臓病モデルラットの骨代謝維持に 対する食餌アルギニンあるいは大豆イソフラボン抽出物 投与の有効性評価に関する基礎的研究

海老沢, 秀道  ,  岩谷, 美咲  ,  鬼窪, 麻衣  ,  瀧山, 花穂  ,  竹本, 歩実  ,  松本, 美寿穂  ,  清水, 史子

(914)  , pp.6 - 14 , 2016-12-01 , 昭和女子大学近代文化研究所
ISSN:1348-0103
内容記述
The present study was carried out to elucidate the protective effects of dietary L-arginine and soy isoflavone-extracted on the bone metabolism in the ovariectomized chronic kidney disease model rats.  Nine-week-old female rats received 360mg/kg BW of adenine intragastrally for four consecutive days so that they would develop chronic kidney disease(CKD). After six days of recovery, rats received ovariectomies(OVX)under anesthesia. A sham operation was carried out on another group of rats(group Intact).  Seven days after the OVX, the rats were given either a control diet(20% casein protein diet(group CA); 0.5% L-arginine supplemented diet(group Arg); or 0.20% soy isoflavone-extracted supplemented diet(group IF), 13g per day for 12 weeks. Rats in group Intact were, like group CA, given the control diet.  The results were as follows: 1)Group CA developed moderate chronic kidney disease which was manifested as elevated kidney weight, increased serum creatinine, relatively lower creatinine clearance and reduced femoral-BMD than that of group Intact.2)The L-Arginine supplemented diet did not improve renal function and femoral BMD-loss. But, increased mRNA expression levels of IGF-1, BMP-2 and Osterix were observed in the femurs.3)Soy isoflavone-extracted supplemented diet had no preventative effects on BMD loss, although estrogen receptor-beta mRNA expression levels in the femurs were elevated.  From these results, bone-protective functions of L-arginine via activation of osteoblast differentiation and bone formation process were suggested. Further investigation to clarify the efficacy of L-arginine-IGF-1 signal transduction on the bone metabolism is required to determine whether a therapy based on this approach can help people suffering from osteoporosis in CKD patients.
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