Departmental Bulletin Paper Effects of a High-NaCl Diet on Pressure- Natriuresis in Young Zucker Fatty Conditions
Effects of a High-NaCl Diet on Pressure- Natriuresis in Young Zucker Fatty Conditions

中西, 員茂

(902)  , pp.14 - 20 , 2015-12-01 , 昭和女子大学
ISSN:13480103
NCID:AN00038441
Description
Background: Renal mechanisms of sodium homeostasis are reportedly impaired in obese subjects. However, the precise contribution of a high-sodium diet to pressure-natriuresis in Zucker fatty rats (ZFR) remains unclear. The purpose of this study was to evaluate whether a high-sodium diet affects the blunted pressure-natriuretic response in ZFR.Methods: This study examined responses of pressure-natriuresis using laser Doppler flowmetry techniques when the NaCl diet was altered (0.4% or 4%) in young ZFR and estimated cortical and medullary blood flow (MBF) distributions.Results: Systolic arterial pressure was significantly higher for ZFR+high NaCl than for ZFR+low NaCl. The slope of the pressure-natriuresis curve was significantly lower in ZFR+high NaCl than in ZFR+low NaCl. In ZFR+high NaCl, MBF was also significantly lower than in Zucker lean rats (ZLR) at a renal perfusion pressure of 140 mmHg without any substantial changes in total renal blood flow or cortical blood flow. Urinary excretion of nitrites and nitrates was lower in ZFR+high NaCl than in ZLR. Conclusion: These findings suggest that high-NaCl diet, by itself, eliminated the slope of the pressure-natriuresis curve in young ZFR due to decreased MBF, resulting in salt-sensitive hypertension.
Background: Renal mechanisms of sodium homeostasis are reportedly impaired in obese subjects. However, the precise contribution of a high-sodium diet to pressure-natriuresis in Zucker fatty rats (ZFR) remains unclear. The purpose of this study was to evaluate whether a high-sodium diet affects the blunted pressure-natriuretic response in ZFR.Methods: This study examined responses of pressure-natriuresis using laser Doppler flowmetry techniques when the NaCl diet was altered (0.4% or 4%) in young ZFR and estimated cortical and medullary blood flow (MBF) distributions.Results: Systolic arterial pressure was significantly higher for ZFR+high NaCl than for ZFR+low NaCl. The slope of the pressure-natriuresis curve was significantly lower in ZFR+high NaCl than in ZFR+low NaCl. In ZFR+high NaCl, MBF was also significantly lower than in Zucker lean rats (ZLR) at a renal perfusion pressure of 140 mmHg without any substantial changes in total renal blood flow or cortical blood flow. Urinary excretion of nitrites and nitrates was lower in ZFR+high NaCl than in ZLR. Conclusion: These findings suggest that high-NaCl diet, by itself, eliminated the slope of the pressure-natriuresis curve in young ZFR due to decreased MBF, resulting in salt-sensitive hypertension.
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