紀要論文 Central Neural Mechanisms Involved in the Control of Jaw Movement during Postnatal Development

NAKAMURA Shiro:筆頭著者:責任著者  ,  NAGATA Shoko  ,  NONAKA Mutsumi  ,  NISHIMURA Akiko  ,  NAGOYA Kouta  ,  DANTSUJI Masanori  ,  NAKAYAMA Kiyomi  ,  MOCHIZUKI Ayako  ,  IIJIMA Takehiko  ,  OZEKI Masahiko  ,  YAMAMOTO Matsuo  ,  INOUE Tomio

29 ( 3 )  , pp.221 - 229 , 2017-09 , Showa University Society
ISSN:0915-6380
内容記述
Mechanisms responsible for controlling masticatory muscle activity during suckling and mastication initiate in the brain. Premotor neurons situated in the brainstem transmit masticatory motor commands to the jaw-closing and jaw-opening motoneurons, which in turn activate the masticatory muscles. The premotor neurons receive inputs from multiple sources such as the orofacial sensory organs, the cerebral cortex, and the central pattern generator in the brainstem. These neural circuits might be important for controlling jaw movement, although their properties in this regard are likely to be altered in postnatal development as the oral motor behavior of mammals shifts significantly from suckling to chewing during the early postnatal period. This timing of jaw movement development mimics that of the orofacial musculoskeletal apparatus. The current article reviews findings on local neural circuits of trigeminal motoneurons and premotor neurons, during early development in rats. We describe findings from electrophysiological recordings, optical imaging with voltage-sensitive dyes, calcium imaging, and laser photolysis of caged glutamate. We also review research into the subtypes of premotor neurons in the supratrigeminal region (SupV) that differ in their electrophysiological properties and possess different morphological characteristics. We further describe how trigeminal motoneurons receive glutamatergic, glycinergic, and GABAergic inputs from the SupV and the reticular formation dorsal to the facial nucleus. Finally, we discuss how these synaptic and intrinsic membrane properties change in postnatal development. Taken together, the findings reviewed herein suggest that these neural circuits are important in diverse oral motor behaviors, and that their postnatal changes are involved in the transition from suckling to mastication functions.
本文を読む

http://lilitory.showa-u.ac.jp/?action=repository_uri&item_id=4644

https://lilitory.showa-u.ac.jp/?action=repository_action_common_download&item_id=4644&item_no=1&attribute_id=38&file_no=1

このアイテムのアクセス数:  回

その他の情報