Departmental Bulletin Paper Clarithromycin-resistant Mycobacterium Shinjukuense Lung Disease: Case Report and Literature Review

HAYASHI Makoto :筆頭著者:責任著者  ,  MATSUKURA Satoshi  ,  FUNAKI Toshitaka  ,  INOUE Daisuke  ,  KAZUMI Yuko  ,  MITARAI Satoshi  ,  KOKUBU Fumio  ,  SHIKAMA Yusuke

28 ( 4 )  , pp.373 - 377 , 2016-12 , Showa University Society
Mycobacterium shinjukuense is a species of non-tuberculous mycobacteria newly reported in 2010. Herein, we report on an 85-year-old woman with M. shinjukuense lung disease. Radiographic examinations showed consolidation with bronchiectasis, which responded transiently to clarithromycin monotherapy. After 1 year of monotherapy, the diagnosis was established and drug susceptibility testing revealed elevated minimum inhibitory concentration for clarithromycin. The patient was then treated successfully with a combination of antituberculosis drugs. The transient response to clarithromycin suggested that the M. shinjukuense had acquired resistance to clarithromycin. Appropriate treatment for M. shinjukuense lung disease has not yet been established; therefore, it is important to accumulate information from case reports.

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