||Influence of diet and metabolism on hematopoietic stem cells and leukemia development following ionizing radiation exposure
Karabulutoglu, Melis ,
Finnon, Rosemary ,
Imaoka, Tatsuhiko ,
A. Friedl, AnnaBadie, Christophe
International Journal of Radiation Biology
2018-06 , Taylor and Francis
Purpose: The review aims to discuss the prominence of dietary and metabolic regulators in maintaining HSC function, long-term self-renewal and differentiation.Results: Most adult stem cells are preserved in a quiescent, non-motile state in vivo which acts as a “protective state” for stem cells to reduce endogenous stress provoked by DNA replication and cellular respiration as well as exogenous environmental stress. The dynamic balance between quiescence, self-renewal and differentiation is critical for supporting a functional blood system throughout life of an organism. Stress-conditions, e.g. ionizing radiation exposure can trigger the blood forming hematopoietic stem cells (HSCs) to proliferate and migrate through extramedullary tissues to expand the number of HSCs and increase hematopoiesis. In addition, a wealth of investigation validated that deregulation of this balance plays a critical pathogenic role in various different hematopoietic diseases including the leukemia development.Conclusion: The review summarises the current knowledge on how alterations in dietary and metabolic factors could alter the risk of leukemia development following ionizing radiation exposure by inhibiting or even reversing the leukemic progression. Understanding the influence of diet, metabolism and epigenetics on radiation-induced leukemogenesis may lead to the development of practical interventions to reduce the risk in exposed populations.