Presentation The Potential Biomarkers for Screening Lung Cancer Risk in High Residential Radon

Autsavapromporn, Narongchai  ,  Pitchayaponne Klunklin  ,  Chewaskulyong, Busyamas  ,  Tuntiwechapikul, Wirote  ,  Roytrakul, Sittiruk  ,  Rithidech, Kanokporn  ,  Konishi, Teruaki  ,  Hosoda, Masahiro  ,  Tokonami, Shinji

IntroductionConsidering that radon is likely the second most common cause of lung cancer after smoking and the need to incorporate new biomarkers useful for early screening would be promising for the improvement of the treatment outcome. So, our study aims to evaluate the potential clinical use of serum biomarkers and teleomeres length in lung cancer patients and high residential radon.MethodsA passive radon-thoron discriminative monitor (RADUET) using a solid-state track detector (CR-39) was used to evaluate the indoor radon in 227 dwellings in a 5-7 months period. According to indoor radon measurements, serum samples from 38 lung cancer patients and 38 matched healthy controls (low- and high radon group) were analysed for 7 proteins (CEA, Cyfra 21-1, IL-8, TNF-alpha, HE4, MIF, VEGF) and teleomere length using the luminex multiplex assay and monochrome multiplex realtime PCR (MMQPCR), respectively.ResultsThe radon concentration were distributed in the range of 23- 229 Bq/m3 with an average value of 50 Bq/m3. The data indicated that the radon concentration seems quite high when considering the climatic condition and housing structure. Interestingly, the result showed that CEA, Cyfra 21-1, IL-8 levels were significantly higher in lung cancer patients than in healthy volunteers. However, the levels of CEA and IL-8 were higher in high radon group than low radon group. Consequently, a high level of CEA and IL-8 are sound to indicate the at high risk for lung cancer from high radon exposure. Further, lung cancer patients had significantly shorter telomere length compared with healthy controls. This may indicate that shortened telomere length with increased lung cancer risk.ConclusionThe results suggest that CEA, IL-8 and short telomere length should be a useful biomarkers of lung cancer risk in high residential radon area and for future studies on personalized therapy of lung cancer.ReferencesUNSCEAR. United Nations Scientific Committee on the Effects of Atomic Radiation. Sources, Effects and risks of ionizing radiation. Report to the General Assembly, United Nations 2000)
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