Journal Article Reduced gray matter volume is correlated with frontal cognitive and behavioral impairments in Parkinson's disease

Terada, Tatsuhiro  ,  Miyata, Jun  ,  Obi, Tomokazu  ,  Kubota, Manabu  ,  Yoshizumi, Miho  ,  Murai, Toshiya

Description
Objective: To identify the brain-volume reductions associated with frontal cognitive and behavioral impairmentsin Parkinson's disease (PD).Methods: Forty PD patients without dementia or amnesia (Hoehn and Yahr stage 3) and 10 age-matched controlsunderwent brain magnetic resonance imaging. Cognitive and behavioral impairments were assessed by using theFrontal Assessment Battery (FAB) and Frontal Systems Behavioral Scale (FrSBe), respectively. We applied voxelbasedmorphometry to investigate the correlations of regional gray matter volume with FAB, FrSBe, and physicaldisability.Results: FAB was significantly lower in PD than in controls. FrSBe was significantly higher after PD onset thanbefore, notably in the apathy subscale. FAB and FrSBe were significantly intercorrelated. In PD patients, leftinferior frontal volume was positively correlated with FAB, whereas right precentral volume was negativelycorrelated with FrSBe total score. The brain volumes in both of these regions were not correlated with theUnified PD Rating Scale III.Conclusion: Behavioral impairments in PD tended to coexist with progression of frontal cognitive impairment.Regional atrophy within the frontal lobe was associated with both frontal cognitive and behavioral impairments.However, the specific region responsible for behavioral impairment differed from that for frontal cognitiveimpairment. These associations were independent of physical disability.

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