会議発表用資料 Disturbed Vocal Communication in Common Marmoset Family with an Autism-Model Child

三村, 喬生

2017-05-16
内容記述
Introduction: Autism spectrum disorder (ASD) is one of the most common developmental disorders. Most children with ASD demonstrate delays in language development. Parents of these children may also feel frustration and stress because they cannot communicate with their children (Hastings, 2002). In rodents, exposure embryos to valproic acid (VPA), known as the risk factor of ASD in human (Christensen, 2013), are widely used as an animal model (Crawley, 2012). Here we show that common marmoset (Callithrix jacchus) families with a juvenile with fatal exposure to VPA show vocalization abnormality.Methods: The experiment was conducted using 16 children of marmosets (9 VPA exposed, and 7 unexposed (UE)) consisting of one or two juveniles (ranging from 1 to 5 months of age) and their respective parents. In the families with VPA exposed children, the dams received seven oral administrations of sodium valproate at 200mg/kg/day from day 60 to 66 after conception. To evaluate the kinship social communication, family (one juvenile and its parents) vocalizations were recorded for 30 minutes in their home cage carried at shield room. Vocal spectrogram was used to define and count 9 call types. All procedures were approved by the Animal Research Committee at the National Institute of Neuroscience in Tokyo, Japan.Results & Discussion: There were significant differences of call-uses between VPA and UE families. In VPA families, social isolation call “phee” frequency and agitation call “twitter” was increased, on the other hand, “trill” call frequency, supposed ‘felling affinity’, was decreased. These two groups were significantly discriminated by outlier analysis based on Mahalanobis’ distance. It is suggested that quantitative analysis of verbal communication in family with ASD children could be useful and noninvasive criterion of patient himself and his family.
24th International "Stress and Behavior" Neuroscience and Biopsychiatry Conference

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