Presentation Identification of Potential New Biomarkers for Early Detection of Lung Cancer Risk in High Residential Radon: A Preliminary Study in Chiang Mai, ThailandIdentification of Potential New Biomarkers for Early Detection of Lung Cancer Risk in High Residential Radon: A Preliminary Study in Chiang Mai, Thailand

Autsavapromporn, Narongchai  ,  Klunklin, Pitchayaponne  ,  Chewaskulyong, Busyamas  ,  Tuntiwechapikul, Wirote  ,  Wongnoppavich, Ariyapong  ,  Amphol, Suwapat  ,  Roytrakul, Sittiruk  ,  Rithidech, Kanokporn  ,  Konishi, Teruaki  ,  Hosoda, Masahiro  ,  Tokonami, Shinji

Lung cancer is a major cause of cancer-related death worldwide and shows high incidences in Chiang Mai. The major reasons for the increasing incidence rate are smoking, radon and air pollution. In this context, the potential biomarker useful for early screening would be promising for the improvement of the treatment outcome and the reduction of mortality. However, suitable biomarkers for lung cancer risk based on radon exposure have not yet been examined and identified by any research works. So, our study aims to investigate the potential biomarkers based on the estimation of the radon concentration in Chiang Mai. Then, the estimation result will be analyzed in order to distinguish low-and high residential radon exposure in comparison with lung cancer patients.A passive radon-thoron discriminative monitor was used to evaluate the indoor radon in 55 dwellings in a 10-12 months period which are specifically selected according to the number of lung cancer. According to indoor radon measurements, serum samples from 38 lung cancer patients and 38 matched healthy controls (19 low-and 19 high- radon group) were analysed for CEA, Cyfra 21-1, IL-8, TNF-, HE4, MIF, VEGF levels using the luminex multiplex assay.The radon concentration in 55 dwellings were distributed in the range of 35- 219 Bq/m3 with an average value of 57 Bq/m3. While, the worldwide average indoor radon concentration is at 39 Bq/m3. Therefore, the result indicated that the concentration of radon in our study area seems quite high when considering the climatic condition and housing structure. More importantly, the result showed that CEA, Cyfra 21-1, IL-8 levels were significantly higher in lung cancer patients than in healthy controls. Interestingly, levels of CEA and IL-8 were higher in high radon than low radon group. Consequently, a high level of CEA and IL-8 are sound to indicate the at high risk for lung cancer from high radon exposure. Therefore, IL-8 can be a new potential biomarker for screening lung cancer from radon exposure.
Consortium of Biological Sciences 2017 (ConBio 2017)

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