Journal Article A Strategy to Design Hyperpolarized 13 C Magnetic Resonance Probes Using [1-13 C]α-Amino Acid as a Scaffold Structure

Nishihara, Tatsuya  ,  Kameyama, Yutaka  ,  Nonaka, Hiroshi  ,  Takakusagi, Yoichi  ,  Hyodo, Fuminori  ,  Ichikawa, Kazuhiro  ,  Sando, Shinsuke

12 ( 9 )  , pp.949 - 953 , 2017-04 , Wiley
ISSN:1861-4728
Description
Hyperpolarization is an emerging method that dramatically enhances NMR signal intensity. As a result of their increased sensitivity, hyperpolarized (HP) NMR molecular probes can be used to perform time-resolved spectroscopy and imaging in vitro and in vivo. It is, however, challenging to design such probes de novo. Herein, the [1-13C]a-amino acid is reported as a scaffold structure to design HP 13C NMR molecular probes. The [1-13C]a-amino acid can be converted to various HP 13C chemical probes that show sufficient chemical shift change by altering the chemical state of the a nitrogen upon interaction with the target. Several previously reported HP probes could be explained by this design principle. To demonstrate the versatility of this approach, two a-amino-acid-based HP 13C chemical probes, sensitive to pH and Ca2+ ion, were developed and used to detect targets.

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