Journal Article Clinical Impact of Re-irradiation with Carbon-ion Radiotherapy for Lymph Node Recurrence of Gynecological Cancers

Shiba, Shintaro  ,  Okonogi, Noriyuki  ,  Kato, Shingo  ,  Wakatsuki, Masaru  ,  Kobayashi, Daijiro  ,  Kiyohara, Hiroki  ,  Ohno, Tatsuya  ,  Karasawa, Kumiko  ,  Nakano, Takashi  ,  Kamada, Tadashi

37 ( 10 )  , pp.5577 - 5583 , 2017-10
AbstractBACKGROUND/AIM: To evaluate the safety and efficacy of re-irradiation with carbon-ion radiotherapy (C-ion RT) for lymph node recurrence of gynecological cancers after definitive radiotherapy.PATIENTS AND METHODS: Data regarding patients with unresectable and isolated recurrent lymph node from gynecological cancer after definitive radiotherapy were analyzed. Total dose of C-ion RT was 48-57.6 Gy (RBE) in 12 or 16 fractions.RESULTS: Sixteen patients received re-irradiation by C-ion RT were analyzed. Median follow-up was 37 months. Median tumor size was 27 mm. None developed Grade 1 or higher acute toxicities and Grade 3 or higher late toxicities. The 3-year overall survival, local control and disease-free survival rates after C-ion RT were 74%, 94% and 55%, respectively.CONCLUSION: Re-irradiation with C-ion RT for lymph node recurrence of gynecological cancers after definitive radiotherapy can be safe and effective. This result suggested that C-ion RT could be a curative treatment option for conventionally difficult-to-cure patients.

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