Journal Article Multi-institutional retrospective study of mucoepidermoid carcinoma treated with carbon-ion radiotherapy.

Shirai, Katsuyuki  ,  Koto, Masashi  ,  Demizu, Yuusuke  ,  Suefuji, Hiroaki  ,  Ohno, Tatsuya  ,  Tsuji, Hiroshi  ,  Okimoto, Tomoaki  ,  Shioyama, Yoshiyuki  ,  Saitou, Jyunnichi  ,  Nemoto, Kenji  ,  Nakano, Takashi  ,  Kamada, Tadashi

108 ( 7 )  , pp.1447 - 1451 , 2017-07
AbstractThis study aimed to evaluate the clinical outcomes of patients with mucoepidermoid carcinomas in the head and neck treated with carbon-ion radiotherapy. Data from 26 patients who underwent carbon-ion radiotherapy in four facilities were analyzed in this multi-institutional retrospective study: the Japan Carbon-ion Radiation Oncology Study Group. The median follow-up time was 34 months. One patient experienced local recurrence, and the 3-year local control rate was 95%. One patient developed lymph node recurrence and five developed distant metastases. The 3-year progression-free survival rate was 73%. Five patients died, two of mucoepidermoid carcinoma and three of intercurrent disease. The 3-year overall survival rate was 89%. Acute mucositis and dermatitis of grade 3 or higher were experienced by 19% and 8% of patients, respectively; these improved with conservative therapy. Late mucositis and osteonecrosis of jaw were observed in 12% and 23% of patients, respectively. The 3-year cumulative rate of any late adverse event of grade 3 or higher was 14%. None of the patients died of the acute or late adverse events. Carbon-ion radiotherapy was efficacious and safe for treating mucoepidermoid carcinoma in this multi-institutional retrospective study (registration no. UMIN000024473). We are currently undertaking a prospective multicenter study.

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