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A Facile Radiolabeling of [18F]FDPA via Spirocyclic Iodonium Ylides: Preliminary PET Imaging Studies in Preclinical Models of Neuroinflammation.A Facile Radiolabeling of [18F]FDPA via Spirocyclic Iodonium Ylides: Preliminary PET Imaging Studies in Preclinical Models of Neuroinflammation. |
"/Wang, Lu/"Wang, Lu ,
"/Cheng, Ran/"Cheng, Ran ,
"/Fujinaga, Masayuki/"Fujinaga, Masayuki ,
"/Yang, Jian/"Yang, Jian ,
"/Zhang, Yiding/"Zhang, Yiding ,
"/Hatori, Akiko/"Hatori, Akiko ,
"/Kumata, Katsushi/"Kumata, Katsushi ,
"/Yang, Jing/"Yang, Jing ,
"/Vasdev, Neil/"Vasdev, Neil ,
"/Du, Yunfei/"Du, Yunfei ,
"/Ran, Chongzhao/"Ran, Chongzhao ,
"/Ming-Rong, Zhang/"Ming-Rong, Zhang ,
"/Steven H. Liang/"Steven H. Liang
60
(
12
)
, pp.5222
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5227 , 2017-05 , ELSEVIER
ISSN:0022-2623
Description
A suitable TSPO PET ligand may visualize and quantify neuroinflammation in a living brain. Herein we report a 18F-ligand, [18F]2 ([18F]FDPA), is radiolabeled in high yield and high specific activity based on our spirocyclic iodonium ylide (SCIDY) strategy. [18F]2 demonstrated saturable specific binding to TSPO, substantially elevated brain uptake, and slow washout of bound PET signal in the preclinical models of brain neuroinflammation (cerebral ischemia and Alzheimer's disease).
