学術雑誌論文 A Facile Radiolabeling of [18F]FDPA via Spirocyclic Iodonium Ylides: Preliminary PET Imaging Studies in Preclinical Models of Neuroinflammation.

Wang, Lu  ,  Cheng, Ran  ,  Fujinaga, Masayuki  ,  Yang, Jian  ,  Zhang, Yiding  ,  Hatori, Akiko  ,  Kumata, Katsushi  ,  Yang, Jing  ,  Vasdev, Neil  ,  Du, Yunfei  ,  Ran, Chongzhao  ,  Ming-Rong, Zhang  ,  Steven H. Liang

60 ( 12 )  , pp.5222 - 5227 , 2017-05 , ELSEVIER
ISSN:1520-4804
内容記述
A suitable TSPO PET ligand may visualize and quantify neuroinflammation in a living brain. Herein we report a 18F-ligand, [18F]2 ([18F]FDPA), is radiolabeled in high yield and high specific activity based on our spirocyclic iodonium ylide (SCIDY) strategy. [18F]2 demonstrated saturable specific binding to TSPO, substantially elevated brain uptake, and slow washout of bound PET signal in the preclinical models of brain neuroinflammation (cerebral ischemia and Alzheimer's disease).

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