Journal Article Age and gender effects of 11C-ITMM binding to metabotropic glutamate receptor type 1 in healthy human participants.

Sakata , Muneyuki  ,  Toyohara, Jun  ,  Ishibashi, Kenji  ,  Wagatsuma, Kei  ,  Ishii, Kenji  ,  Ming-Rong, Zhang  ,  Ishiwata, Kiichi

55pp.72 - 77 , 2017-03 , Elsevier
We examined possible age- and gender-related changes in bindingof the selective antagonist N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-4-11C-methoxy-N-methylbenzamide (11C-ITMM) to metabotropicglutamate receptor type 1 (mGluR1) in healthy human brains.Dynamic 11C-ITMM positron emission tomography scans (90 min) with serialarterial blood sampling were performed in 15 young and 24 older healthyadult volunteers. The total distribution volume (VT) of several brainregions was estimated with two-tissue compartment model analysis.The VTs of the cerebellar cortex, parietal cortex, putamen, amygdala, andhippocampus in older adult participants were significantly higher than inyoung participants. The age-related VT increase was only observed in maleparticipants.Our data suggest that an age-dependent increase in mGluR1 availability inseveral brain regions may exist predominantly in males.

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