学術雑誌論文 Use of human methylation arrays for epigenome research in the common marmoset (Callithrix jacchus)

Ueda, Junko  ,  Murata, Yui  ,  Bundo, Miki  ,  Arata, Oh-Nishi  ,  Kasai, Hidetoshi  ,  Ikegame, Tempei  ,  Zhao, Zhilei  ,  Jinde, Seiichiro  ,  Aiba, Atsu  ,  須原, 哲也  ,  Kasai, Kiyoko  ,  Kato, Tadafumi  ,  Iwamoto, Kazuya

2017-02 , Neuroscience Research
内容記述
tWe examined the usefulness of commercially available DNA methylation arrays designed for the humangenome (Illumina HumanMethylation450 and MethylationEPIC) for high-throughput epigenome analysisof the common marmoset, a nonhuman primate suitable for research on neuropsychiatric disorders. Fromamong the probes on the methylation arrays, we selected those available for the common marmoset. DNAmethylation data were obtained from genomic DNA extracted from the frontal cortex and blood samplesof adult common marmosets as well as the frontal cortex of neonatal marmosets. About 10% of the probeson the arrays were estimated to be useful for DNA methylation assay in the common marmoset. Strongcorrelations existed between human and marmoset DNA methylation data. Illumina methylation arraysare useful for epigenome research using the common marmoset.

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