Presentation 婦人科腫瘍に対する重粒子線治療における晩期有害事象と線量体積分布に関する研究

小此木, 範之

2017-04-17
Description
Normal tissue constraints for organ at risks (OARs) are not well-standardized in carbon-ion radiotherapy (C-ion RT). In this study, we analyzed dosimetric data of pelvic OARs in patients with gynecologic tumor, and examine corresponding late toxicity to OARs. The treatment plans of 99 patients who underwent C-ion RT for gynecologic tumor were reviewed. Dose-volume histogram (DVH) statistics were recalculated for rectum and bladder using recent planning software (Xio-N). DVH data were analyzed and correlated with the development of late toxicity. The median follow-up period was 38 months(range: 6-238 months). Thirty- one patients developed late rectal toxicity, and 19 patients developed late bladder toxicity. The values of V50 for rectum were 10.3 cc(±7.3) and 6.4 cc (±6.3) in the patients with toxicity and without toxicity, respectively (p=0.009). The values of V60 for rectum were 3.2 cc (±4.8)and 1.1 cc (±1.9)in the patients with toxicity and without toxicity, respectively (p=0.024). V40, V70, and Dmax did not show statistical significance. Meanwhile, the values of V50 for bladder were 54.1 cc (±31.3) and 36.4 cc (±26.7) In the patients with toxicity and without toxicity, respectively (p=0.015). V40, V60, V70, and Dmax did not show statistical significance.
平成28年度HIMAC共同利用研究成果発表会

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