一般雑誌記事 Combining Carbon-ion Beam and NHEJ Repair Inhibitor NU7026 Efficiently Kills Cancer Cells

高橋, 昭久 (群馬大)  ,  馬, 洪玉 (群馬大)  ,  五十嵐, 千恵 (群馬大)  ,  吉田, 由香里 (群馬大)  ,  舟山, 知夫  ,  小林, 泰彦

pp.114 - 114 , 2017-03 , Takasaki Advanced Radiation Research Institute, QST
内容記述
To evaluate a contribution of two major DSB repair pathways in killing of human cancer cells, we determined if combining irradiation with a Carbon-ion (C-ion) beam and NHEJ inhibitor more could efficiently kill human cancer cells compared with HR inhibitor. The result indicated that NHEJ inhibition increases cytotoxicity of human tumor cells to irradiation with carbon ions more efficiently relative to HR inhibition.

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