||Epigenetic Modifier as a Potential Radiosensitizer for Heavy-ion Therapy on Malignancy (IV)
斎藤, 克代 ,
舟山, 知夫 ,
小林, 泰彦村上, 孝 (高崎健康福祉大)
QST Takasaki Annual Report 2015
115 , 2017-03 , Takasaki Advanced Radiation Research Institute, QST
To evaluate sensitizing effect of HDACis in combination with heavy-ion radiation, murine melanoma cells were treated with several HDACis, irradiated with carbon ion beam, and the phosphorylation of H2AX, a molecular marker for DNA double strand break, was measured by Western blotting. The result revealed that there were lower phosphorylation of H2AX in carbon ion irradiated cells than that of γ-ray irradiated, although the sensitization effect of clonogenic survival was higher in carbon ion irradiation.