Article Epigenetic Modifier as a Potential Radiosensitizer for Heavy-ion Therapy on Malignancy (IV)

斎藤, 克代  ,  舟山, 知夫  ,  小林, 泰彦  ,  村上, 孝 (高崎健康福祉大)

pp.115 - 115 , 2017-03 , Takasaki Advanced Radiation Research Institute, QST
To evaluate sensitizing effect of HDACis in combination with heavy-ion radiation, murine melanoma cells were treated with several HDACis, irradiated with carbon ion beam, and the phosphorylation of H2AX, a molecular marker for DNA double strand break, was measured by Western blotting. The result revealed that there were lower phosphorylation of H2AX in carbon ion irradiated cells than that of γ-ray irradiated, although the sensitization effect of clonogenic survival was higher in carbon ion irradiation.

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