Journal Article Respiration-gated fast-rescanning carbon-ion radiotherapy

エブナー, ダニエル  ,  辻, 比呂志  ,  安田, 茂雄  ,  山本, 直敬  ,  森, 慎一郎  ,  鎌田, 正

47 ( 1 )  , pp.80 - 83 , 2017-01 , OXFORD Academic
Phase-controlled rescanning of the carbon-ion beam offers fast and precise dose application with decreased irradiation of normal tissue. However, organ movement with respiration remains a unique challenge. Technological development has enabled the simultaneous application of beam- energy-modulated markerless phase-controlled rescanning with respiration gating, allowing scan- ning treatment of respiration-mobile tumors with carbon. A total of 10 patients with tumors in the liver or lung were treated in a feasibility study at our facility using this combination. At a median of 10.5 months, follow-up examination including computed tomography/magnetic resonance imaging revealed no grade 2+ acute adverse effects with this new therapy. Two patients with complex disease experienced local recurrence, which may be improved with increased dose deliv- ery. One patient died of unrelated causes. All other patients are alive with good control at the time of writing. Though long-term observation is pending, these are promising initial results for use of the carbon-beam phase-controlled rescanning method in respiration-mobile disease.

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