学術雑誌論文 DNA damage response induces structural alterations in histone H3-H4.

Izumi, Yudai  ,  Fujii, Kentaro  ,  Yamamoto, Satoshi  ,  Matsuo, Koichi  ,  Namatame, Hirofumi  ,  Taniguchi, Masaki  ,  Yokoya, Akinari

58 ( 1 )  , pp.59 - 65 , 2017-01 , Oxford University Press
ISSN:0449-3060
内容記述
Synchrotron-radiation circular-dichroism spectroscopy was used to reveal that the DNA damage response induces a decrement of α-helix and an increment of β-strand contents of histone H3-H4 extracted from X-ray-irradiated human HeLa cells. The trend of the structural alteration was qualitatively opposite to that of our previously reported results for histone H2A-H2B. These results strongly suggest that histones share roles in DNA damage responses, particularly in DNA repair processes and chromatin remodeling, via a specific structural alteration of each histone.

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