Journal Article Association between Aβ and tau accumulations and their influence on clinical features in aging and Alzheimer’s disease spectrum brains: A [11C]PBB3-PET study

Shimada, Hitoshi  ,  Kitamura, Soichiro  ,  Shinoto, Hitoshi  ,  Endo, Hironobu  ,  Niwa, Fumitoshi  ,  Hirano, Shigeki  ,  Ming-Rong, Zhang  ,  Suhara, Tetsuya  ,  Higuchi, Makoto  ,  Kimura, Yasuyuki  ,  Kuwabara, Satoshi

6pp.11 - 20 , 2017-01 , Elsevier
INTRODUCTION:Amyloid-β (Aβ) and tau accumulations may occur independently and concurrently as exemplified by primary age-related tauopathy and Alzheimer's disease (AD), respectively. Interactions between Aβ and tau accumulations and their influence on clinical features, however, are still unclear.METHODS:Associations among clinical symptoms, gray-matter volume, regional tau, and Aβ deposition assessed by positron emission tomography with [11C]pyridinyl-butadienyl-benzothiazole 3 (PBB3) and [11C]Pittsburgh compound-B (PiB), were evaluated in 17 AD, 9 mild cognitive impairment due to AD, and 28 PiB(-)-cognitive healthy controls (HCs).RESULTS:High tau burden was associated with aging and low-level education in PiB(-)-HC and AD-spectrum groups, and with high Aβ burden and low-level education in all subjects. It was not Aβ but tau accumulation that showed significant associations with cognitive performance even in PiB(-)-HC.DISCUSSION:The present study indicated aging and low-level education after Aβ would be enhancers for tau pathology, associated with neurodegeneration and cognitive impairment in healthy and diseased elderly individuals.

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