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Association between Aβ and tau accumulations and their influence on clinical features in aging and Alzheimer’s disease spectrum brains: A [11C]PBB3-PET studyAssociation between Aβ and tau accumulations and their influence on clinical features in aging and Alzheimer’s disease spectrum brains: A [11C]PBB3-PET study |
"/Shimada, Hitoshi/"Shimada, Hitoshi ,
"/Kitamura, Soichiro/"Kitamura, Soichiro ,
"/Shinoto, Hitoshi/"Shinoto, Hitoshi ,
"/Endo, Hironobu/"Endo, Hironobu ,
"/Niwa, Fumitoshi/"Niwa, Fumitoshi ,
"/Hirano, Shigeki/"Hirano, Shigeki ,
"/Ming-Rong, Zhang/"Ming-Rong, Zhang ,
"/Suhara, Tetsuya/"Suhara, Tetsuya ,
"/Higuchi, Makoto/"Higuchi, Makoto ,
"/Kimura, Yasuyuki/"Kimura, Yasuyuki ,
"/Kuwabara, Satoshi/"Kuwabara, Satoshi
6pp.11
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20 , 2017-01 , Elsevier
Description
INTRODUCTION:Amyloid-β (Aβ) and tau accumulations may occur independently and concurrently as exemplified by primary age-related tauopathy and Alzheimer's disease (AD), respectively. Interactions between Aβ and tau accumulations and their influence on clinical features, however, are still unclear.METHODS:Associations among clinical symptoms, gray-matter volume, regional tau, and Aβ deposition assessed by positron emission tomography with [11C]pyridinyl-butadienyl-benzothiazole 3 (PBB3) and [11C]Pittsburgh compound-B (PiB), were evaluated in 17 AD, 9 mild cognitive impairment due to AD, and 28 PiB(-)-cognitive healthy controls (HCs).RESULTS:High tau burden was associated with aging and low-level education in PiB(-)-HC and AD-spectrum groups, and with high Aβ burden and low-level education in all subjects. It was not Aβ but tau accumulation that showed significant associations with cognitive performance even in PiB(-)-HC.DISCUSSION:The present study indicated aging and low-level education after Aβ would be enhancers for tau pathology, associated with neurodegeneration and cognitive impairment in healthy and diseased elderly individuals.
