Prediction of the clinical standardized uptake value ratio in amyloid PET imaging using a biomathematical modeling approach towards the efficient development of a radioligand.

Arakawa, Yuma; Nai, YingHwey; Shidahara, Miho; Furumoto, Shozo; Seki, Chie; Okamura, Nobuyuki; Tashiro, Manabu; Kudo, Yukitsuka; Yanai, Kazuhiko; Gonda, Kohsuke; Watabe, Hiroshi

Prediction of the clinical standardized uptake value ratio in amyloid PET imaging using a biomathematical modeling approach towards the efficient development of a radioligand.

"/Arakawa, Yuma/"Arakawa, Yuma , "/Nai, YingHwey/"Nai, YingHwey , "/Shidahara, Miho/"Shidahara, Miho , "/Furumoto, Shozo/"Furumoto, Shozo , "/Seki, Chie/"Seki, Chie , "/Okamura, Nobuyuki/"Okamura, Nobuyuki , "/Tashiro, Manabu/"Tashiro, Manabu , "/Kudo, Yukitsuka/"Kudo, Yukitsuka , "/Yanai, Kazuhiko/"Yanai, Kazuhiko , "/Gonda, Kohsuke/"Gonda, Kohsuke , "/Watabe, Hiroshi/"Watabe, Hiroshi

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

58 ( 8 ) , pp.1285 - 1292 , 2017-01 , Society of Nuclear Medicine

ISSN:0161-5505

Description

Our study aimed to develop a method to mathematically predict the kinetic parameters K1, k2 and BPND of amyloid PET tracers, and finally obtain standardized uptake value ratio (SUVR) values from predicted time-activity curves (TACs) of target and reference regions.

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Other information

publisher	Society of Nuclear Medicine
date	2017-01-10
NIItype	Journal Article
language	eng
pmid	28062596
doi	10.2967/jnumed.116.183566
textversion	none
URL	http://jairo.nii.ac.jp/0409/00023213/en