Journal Article Definitive carbon-ion radiotherapy for locally advanced parotid gland carcinomas.

Koto, Masashi  ,  Hasegawa, Azusa  ,  Takagi, Ryo  ,  Ikawa, Hiroaki  ,  Naganawa, Kensuke  ,  Jun-Etsu, Mizoe  ,  Jingu, Keiichi  ,  Tsujii, Hirohiko  ,  Tsuji, Hiroshi  ,  Kamada, Tadashi  ,  Okamoto, Yoshitaka

39 ( 4 )  , pp.724 - 729 , 2016-12 , John Wiley And Sons
BackgroundThe purpose of this study was to present our evaluation of the safety and efficacy of carbon-ion radiotherapy (C-ion RT) for locally advanced parotid gland carcinomas.MethodsClinicopathological features and outcomes were evaluated in 46 patients receiving C-ion RT for parotid gland carcinomas.ResultsSixteen patients had adenoid cystic carcinoma; 8 had adenocarcinoma, 8 had mucoepidermoid carcinoma, and 14 had other carcinomas. T2, T3, T4a, and T4b diseases were diagnosed in 3, 18, 8, and 17 patients, respectively. C-ion RT was provided to 25 patients as the primary treatment, to 20 patients for local recurrences after surgery, and to 1 patient for residual tumor after surgery. During follow-up (median duration, 62 months), 5-year local control and overall survival (OS) rates were 74.5% and 70.1%, respectively. Of the 30 patients without facial nerve palsy before C-ion RT, 25 showed no radiation-induced facial nerve palsy.

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