Presentation Nitroxide-enhanced MRI for imaging of small disruptions of blood vessel permeability and redox-status in mice with hypercholesterolemia

バカロバ, ルミアナ  ,  石井, 伊都子

1Functional and Molecular Imaging Team (fMIT), Department of Molecular Imaging and Theranostics (MIT), National Institute of Radiological Sciences, QST/NIRS, Chiba, Japan2Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, JapanHypercholesterolemia could provoke a disruption of vasculature permeability and redox-homeostasis due to incorporation of abnormal amount of cholesterol in the cellular membranes of endothelial and epithelial cells of vessel wall, as well as in the tissues. The small changes in cell and vasculature permeability are accompanied with changes in membrane transport and cell signaling, which has a significant impact in the etiology of many diseases accompanied with hypercholesterolemia – cancer, neurodegeneration, diabetes, cardiovascular, etc.The present the study was designed to investigate the possibility for detection of very small changes in blood vessel permeability and tissue redox-status in the brain of mice, subjected to high cholesterol diet, using magnetic resonance imaging (MRI) and nitroxides as redox-sensitive contrast substances. Conventional Gd-DTPA was used for comparison.The study is supported by “Diversity program”.
ダイバーシティCHIB 研究環境促進コンソーシアム・共同研究シンポジウム

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