会議発表用資料 低線量或は高線量X線被ばく後のマウス肝臓におけるメタボローム解析

中島, 徹夫  ,  Vares, Guillaume  ,  二宮, 康晴  ,  王, 冰  ,  勝部, 孝則  ,  田中, 薫  ,  劉, 翠華  ,  平川, 博一  ,  丸山, 耕一  ,  藤森, 亮  ,  根井, 充

2016-11-27
内容記述
Radiation induces many molecular alterations in organisms. Biological markers, which indicate radiation effects and are used for predicting late effects in the future, are expected to be identified. Metabolomics has attracted much attention. Low molecular weight metabolites, which are more directly related to biological activities in organisms than DNA or proteins, are evaluated in metabolomics. Here, metabolic analyses were performed in livers of mice irradiated at 0.1, 0.5 and 2 Gy with X-rays. Dose-dependent or dose-specific alterations were evaluated. Metabolites in the liver were analyzed by CE-TOFMS at one month after irradiation. Altered metabolites will be discussed in the viewpoint of characters and usage as biomarkers for evaluating radiation effects.
第54回日本生物物理学会年会

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