Presentation Development of a Prototype OpenPET-Guided Surgery System

Tashima, Hideaki  ,  Yoshii, Yukie  ,  Iwao, Yuma  ,  Yoshida, Eiji  ,  Wakizaka, Hidekatsu  ,  Takuwa, Hiroyuki  ,  Yamaya, Taiga

Tumors diagnosed as malignant are generally removed surgically. However, in cases where the tumors are widely and complexly distributed and they move with organs or they are located on the backside of the organs, it is challenging to remove all the tumors in one surgery. To deal with this problem, we are developing the OpenPET-guided surgery system which can provide sufficient open space for surgical operation during PET measurement. In this study, we developed a small prototype and demonstrated a tumor extirpation surgery of a mouse. In order to display images immediately after the data acquisition, we developed a real-time imaging system by implementing the one-pass 3D list-mode DRAMA on the GPU. Because it is difficult to find tumors in images reconstructed with too short time frames due to low count statistics while the time required for identifying tumor locations is desired to be short, we implemented the system so that the displayed images became clearer gradually as the data accumulation time increased. For a demonstrational surgery, human colon carcinoma HCT116-RFP cells had been intraperitoneally transplanted into a mouse. One hour after 18F-FLT injection of 3.7 MBq, the mouse was set onto the operation table inside the FOV of the OpenPET for an abdominal operation. Tumor locations were identified before and after the isolation. Measurement time required to acquire sufficient numbers of data to visually identify the tumors from background radioactivity with clear contrast was about 20-30 s. Images were reconstructed with the computational time of less than 1 s, and displayed images became gradually clearer every second. We could observe the tumors were successfully isolated from the body. The surgery demonstrated that the system allowed us to confirm tumor positions anytime during the operation. We concluded that the proposed system was effective in preventing any tumors, especially those located behind organs, from being left after the surgery.

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