学術雑誌論文 A Facile and Rapid Access to Resveratrol Derivatives and Their Radioprotective Activity

Uzura , Saori  ,  Sekine, Emiko  ,  Nakanishi, Ikuo  ,  Sonoda, Motohiro  ,  Tanimori, Shinji

26 ( 16 )  , pp.3886 - 3891 , 2016-08 , Elsevier
ISSN:0960-894x
内容記述
A facile and rapid access to resveratrol derivatives has been achieved based on palladium-catalyzed oxidative Heck reaction of aryl moronic acids with styrenes followed by demethylation in moderate to good yields. A series of resveratrol derivatives with various functional groups has been synthesized easily. The radio protective activity of synthesized compounds has also been evaluated using rat thymocytes. The results revealed that some resveratrol derivatives efficiently protected the thymocytes from radiation-induced apoptosis.

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