Journal Article Carbon-Ion Radiation Therapy for Pelvic Recurrence of Rectal Cancer

Yamada, Shigeru  ,  Kamada, Tadashi  ,  Ebner, Daniel  ,  Shinoto, Makoto  ,  Terashima, Koutaro  ,  Isozaki, Yuka  ,  Yasuda, Shigeo  ,  Makishima, Hirokazu  ,  Tsuji, Hiroshi  ,  Tsujii, Hirohiko  ,  Isozaki, Teturo  ,  Endo, Satoshi  ,  Takahashi, Keiichi  ,  Sekimoto, Mitsugu  ,  Saitou, Norio  ,  Matsubara, Hisahiro

Purpose: Investigation of the treatment potential of carbon-ion radiation therapy in pelvic recurrence of rectal cancer.Patients and Methods: A phase 1/2 dose escalation study was performed. One hundred eighty patients (186 lesions) with locally recurrent rectal cancer were treated with carbon-ion radiation therapy (CIRT) (phase 1/2: 37 and 143 patients, respectively).The relapse locations were 71 in the presacral region, 82 in the pelvic sidewalls, 28 in the perineum, and 5 near the colorectal anastomosis. A 16-fraction in 4 weeks dose regimen was used, with total dose ranging from 67.2 to 73.6 Gy(RBE); RBE-weighted absorbed dose: 4.2 to 4.6 Gy(RBE)/fraction.

Number of accesses :  

Other information