Presentation Vascular Elasticity Measured by Novel Brachial Artery Vascular Volume Elastic Modulus With Automated Oscillometry Reflects Molecular Determinant of Vascular Fibrosis

Yoshinaga, Keiichiro  ,  Tomiyama, Yuuki  ,  Fujii, Satoshi  ,  Ochi, Noriki  ,  Katoh, Chietsugu  ,  Inoue, Mamiko  ,  Nishida, Mutumi  ,  Takeuchi, Keisuke  ,  M. Ito, Yoichi  ,  Tamaki, Nagara

Background: Simple vascular functional measurements are desirable for atherosclerosis risk assessments. Recently, we developed a novel modality of automated oscillometric method to measure a brachial artery’s vascular elastic modulus (VE). Galectin-3 (Gal-3) expressed in endothelial cells regulates vascular fibrosis and is a molecular determinant of vascular stiffness. We aimed to clarify whether VE selectively correlates with marker of vascular stiffness in chronic kidney disease (CKD). Methods: 12 moderate-to-severe CKD (mean eGFR 25.9±23.5mL/min/1.73m2) and 15 controls were studied. Rest VE in brachial artery was measured by new automated oscillometric detector. VE was defined as follows [VE =ΔPressure/(100XΔarea/Area) mmHg/%]. Using ultrasound, the brachial artery’s reactive hyperemia [flow mediated dilatation (FMD)] was measured. Gal-3 and interleukin-6 were measured by enzyme-linked immunosorbent assay.Results: CKD had lower FMD (4.86±3.37 vs 9.05±2.98 %, P=0.003) and had attenuated VE than control (1.08±0.26 vs 0.83±0.17 mmHg/%, P=0.002). CKD had higher interleukin-6 (0.67±0.29 vs 0.29±0.33 pg/mL, P=0.003) and Gal-3 (20.0±12.4 vs. 5.84±2.83 pg/mL, P<0.001). VE was correlated negatively with %FMD (r=-0.46, P=0.015) and positively with Gal-3 (r=0.40, P=0.036) but not with interleukin-6 (r=0.21, P=0.28).Conclusions: Attenuated vascular elasticity detected by this novel approach closely correlated with increase in Gal-3 and reduced FMD in CKD. This may indicate that the attenuated vascular elasticity selectively reflects vascular fibrosis as evidenced by Gal-3 and subsequent endothelial responses to vascular stiffness.

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