Journal Article Imaging the role of TLR4 on cell proliferation and inflammation after cerebral ischemia by PET

Moraga, Ana  ,  Vanessa, Gómez-Vallejo  ,  María, Isabel Cuartero  ,  Szczupak, Boguslaw  ,  Eneko, San Sebastián  ,  Markuerkiaga, Irati  ,  Jesús, M. Pradillo  ,  Higuchi, Makoto  ,  Llop, Jordi  ,  María, Ángeles Moro  ,  Abraham, Martín  ,  Lizasoain, Ignacio

The influence of Toll-Like Receptor 4 (TLR4) on neurogenesis and inflammation has been scarcely explored so far by using neuroimaging techniques. For this purpose, we performed magnetic resonance imaging (MRI) and positron emission tomography (PET) with [18F]FLT and [11C]PK11195 at 2, 7 and 14 days following cerebral ischemia in TLR4+/+ and TLR4-/- mice. MRI showed similar infarction volumes in both groups. Despite this, PET with [18F]FLT and [11C]PK11195 evidenced an increase of neurogenesis and a decrease of inflammation in TLR4-/- mice after ischemia. These results evidence the versatility of neuroimaging techniques to monitor the role of TLR4 after cerebral ischemia.

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