Article Induction of Adaptive Response in Mice in vivo and in utero.

王, 冰  ,  田中, 薫  ,  Vares, Guillaume  ,  二宮, 康晴  ,  丸山, 耕一  ,  尚, 奕  ,  藤田, 和子  ,  笠井, 清美  ,  根井, 充

277pp.41 - 46 , 2015-08 , 放射線医学総合研究所 
Induction of adaptive response (AR) by combination of irradiation with different LET values was attempted in a series of investigations in young adult female mice and in fetal mice of C57BL/6J strain using mainly thirty-day survival in vivo, and prenatal death and malformation in utero as endpoints. For total body irradiations, X-rays and high LET accelerated heavy ion irradiations including carbon, silicon, neon and iron particles were used. Significant suppression of mouse death in vivo and marked reduction of prenatal death and malformation in utero were used as criteria for judgment of a successful AR induction. In the past 6 years, nine combinations in the in utero studies and twenty-three combinations in the in vivo studies were performed. Results showed that induction of AR is an event depending on the LET or/and species of the ions. Generally, it is hardly to induce AR by X-rays against heavy ion irradiations with very high LET values, and high LET heavy ion irradiations hardly induce AR against X-rays or higher LET heavy ion irradiations. These findings are expected to contribute to the risk estimation, mechanism study, and practical applications to active induction of radioresistance and to cancer therapy with heavy ion irradiations.

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