Journal Article γ-PARCEL: Control of Molecular Release Using γ-Rays.

Murayama, Shuhei  ,  Jun-Ichiro, Jo  ,  Arai, Kazutaka  ,  Nishikido, Fumihiko  ,  Bakalova, Rumiana  ,  Yamaya, Taiga  ,  Saga, Tsuneo  ,  Kato, Masaru  ,  Aoki, Ichio

87 ( 23 )  , pp.11625 - 11629 , 2015-12
We previously have developed the photoresponsive tetra-gel and nanoparticles for controlling the function of the encapsulated substance by UV irradiation. However, the penetration ability of the UV is not high enough. Here, we developed a radiation-responsive tetra-gel and nanoparticle based on γ-ray-responsive X-shaped polyethylene glycol (PEG) linker with a disulfide bond. The nanoparticle could retain small molecules and biomacromolecules. γ-Rays were used as a trigger signal because of their higher penetrating ability. This allowed a spatiotemporal release and control of the encapsulated substances from the nanoparticle in the deeper region, which is impossible by using light exposure (ultraviolet, visible, and near-infrared).

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