Journal Article Liposomally formulated phospholipid-conjugated indocyanine green for intra-operative brain tumor detection and resection.

Suganami, Akiko  ,  Iwadate, Yasuo  ,  Shibata, Sayaka  ,  Yamashita, Masamichi  ,  Tanaka, Tsutomu  ,  Shinozaki, Natsuki  ,  Aoki, Ichio  ,  Saeki, Naokatsu  ,  Shirasawa, Hiroshi  ,  Okamoto, Yoshiharu  ,  Tamura, Yutaka

496 ( 2 )  , pp.401 - 406 , 2015-10
Some tumor-specific near-infrared (NIR) fluorescent dyes such as indocyanine green (ICG), IDRye800CW, and 5-aminolevulinic acid have been used clinically for detecting tumor margins or micro-cancer lesions. In this study, we evaluated the physicochemical properties of liposomally formulated phospholipid-conjugated ICG, denoted by LP-iDOPE, as a clinically translatable NIR imaging nanoparticle for brain tumors. We also confirmed its brain-tumor-specific biodistribution and its characteristics as the intra-operative NIR imaging nanoparticles for brain tumor surgery. These properties of LP-iDOPE may enable neurosurgeons to achieve more accurate identification and more complete resection of brain tumor.

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