Presentation Reactivity of 2,2-Diphenyl-1-picrylhydrazyl Radical Solubilized in Water by beta-Cyclodextrin and Its Derivatives

Nakanishi, Ikuo  ,  Ohkubo, Kei  ,  Ogawa, Yukihiro  ,  Kamibayashi, Masato  ,  Ozawa, Toshihiko  ,  Fukuzumi, Shunichi  ,  Matsumoto, Kenichiro

Recently, we have reported the solubilization of 2,2-dizhenyl-1-picrylhydrazyl (DPPH) radical in water using beta-cyclodextrin (beta-CD). However, the yield of beta-CD-solubilized DPPH radical is less than 1% due to the poor solubility of beta-CD in water. In this study, the beta-CD derivatives, such as 2,6-di-O-methyl-beta-CD (DM-beta-CD), were used instead of beta-CD to improve the solubility of DPPH radical in water. The scavenging rate constants of DM-beta-CD-solubilized DPPH radical by the water-soluble antioxidants were about half as compared with those of beta-cd-solubilized DPPH.
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