学術雑誌論文 Chronic restraint-induced stress has little modifying effect on radiation hematopoietic toxicity in mice

王, 冰  ,  田中, 薫  ,  Katsube, Takanori  ,  Ninomiya, Yasuharu  ,  Vares, Guillaume  ,  Liu, Qiang  ,  Morita, Akinori  ,  Nakajima, Tetsuo  ,  Nenoi, Mitsuru

56 ( 5 )  , pp.760 - 767 , 2015-09 , OXFORD
内容記述
Both radiation and stresses cause detrimental effects on humans. Besides possible health effects resulting directlyfrom radiation exposure, the nuclear plant accident is a cause of social psychological stresses. A recent study showedthat chronic restraint-induced stresses (CRIS) attenuated Trp53 functions and increased carcinogenesis susceptibilityof Trp53-heterozygous mice to total-body X-irradiation (TBXI), having a big impact on the academic world and asensational effect on the public, especially the residents living in radioactively contaminated areas. It is important toinvestigate the possible modification effects from CRIS on radiation-induced health consequences in Trp53 wild-type(Trp53wt) animals. Prior to a carcinogenesis study, effects of TBXI on the hematopoietic system under CRIS wereinvestigated in terms of hematological abnormality in the peripheral blood and residual damage in the bone marrowerythrocytes using a mouse restraint model. Five-week-old male Trp53wt C57BL/6J mice were restrained 6 h per dayfor 28 consecutive days, and TBXI (4 Gy) was given on the 8th day. Results showed that CRIS alone induced amarked decrease in the red blood cell (RBC) and the white blood cell (WBC) count, while TBXI caused significantlylower counts of RBCs, WBCs and blood platelets, and a lower concentration of hemoglobin regardless of CRIS.CRIS alone did not show any significant effect on erythrocyte proliferation and on induction of micronucleatederythrocytes, whereas TBXI markedly inhibited erythrocyte proliferation and induced a significant increase in theincidences of micronucleated erythrocytes, regardless of CRIS. These findings suggest that CRIS does not have asignificant impact on radiation-induced detrimental effects on the hematopoietic system in Trp53wt mice.

このアイテムのアクセス数:  回

その他の情報