会議発表用資料 Current State of Clinical Imaging for Neuroinflammation

季, 斌

2015-09-02
内容記述
Neuroinflammation is a common pathological change characterized by activation of microglia in many neuropsychiatric and neurodegenerative disease, such as Alzheimer’s disease (AD). 18kDa translocator protein (TSPO), a mitochondrial protein highly expressed in activated glial cells, is a PET-measurable biomarker for neuroinflammation and with the aid of newly developed high-specific radioligands for TSPO and imaging technology, neuroinflammation in response to pathogenetic aggregates such as amyloid and tau, has been longitudinally captured in the living brain of model animals. Our and other research institutions have primarily detected association of neuroinflammation with several neuropsychiatric and neurodegenerative diseases. There, however, are still several concerns in clinical study using TSPO imaging to evaluate neuroinflammation, including what are suitable radioligands and seemingly incompatible result with animal models. One of reasons causing the complexity of imaging in human subject is a polymorphism of human TSPO, which greatly disturb the binding of most of current TSPO radioligands to different extents. Here, I would like talk about the current state of clinical imaging for neuroinflammation in neuropsychiatric and neurodegenerative diseases, potential problems and development of next-generation ligand.
World Molecular Imaging Congress

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