||Designing a ridge filter based on a mouse foot skin reaction to spread out Bragg-peaks for carbon-ion radiotherapy.
Uzawa, Akiko ,
Ando, Koichi ,
Kase, Yuki ,
Hirayama, Ryoichi ,
Matsumoto, Yoshitaka ,
Matsufuji, Naruhiro ,
Koike, SachikoKobashi, Gen
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
283 , 2015-05 , Elsevier Scientific Publishers
Carbon-ion radiotherapy uses spread-out Bragg peaks (SOBP) to produce uniform biological effects within a target volume. The relative biological effectiveness is determined by the in vitro cell kill after a single dose is employed to design the SOBP. A question remains as to whether biological effects for in vivo tissues after fractionated doses are also uniform within the SOBP.