Journal Article Comparison of CD163+ Macrophages and CD206+ Cells in Lesional Skin of CD30+ Lymphoproliferative Disorders of Lymphomatoid Papulosis and Primary Cutaneous Anaplastic Large-cell Lymphoma.

Kakizaki, Aya  ,  Fujimura, Taku  ,  Kambayashi, Yumi  ,  Furudate, Sadanori  ,  Kawano, Mitsuko  ,  Ogasawara, Kouetsu  ,  Aiba, Setsuya

95 ( 5 )  , pp.600 - 602 , 2015-05 , Society for the Publication of Acta Dermato-Venereologica
CD30+ lymphoproliferative disorders represent a spectrum of diseases from lymphomatoid papulosis (LyP) to primary cutaneous anaplastic large-cell lymphoma (PCALCL) (1, 2). LyP is characterized by recurrent papulonodular lesions, which undergo spontaneous regression (1, 2). Survival is unaffected by LyP, but patients are at risk of a second cutaneous or lymphoid malignancy (1). PCALCL has a favourable prognosis with a 5-year survival rate between 76% and 96%. In this report, we used immunohistochemical (IHC) staining of LyP type A and PCALCL specimens to examine for macrophage markers as well as dendritic cell (DC)-specific markers and their functional markers.

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