Journal Article Hybrid Calcium Phosphate-Polymeric Micelles Incorporating Gadolinium Chelates for Imaging-Guided Gadolinium Neutron Capture Tumor Therapy.

Mi, Peng  ,  Dewi, Novriana  ,  Yanagie, Hironobu  ,  Kokuryo, Daisuke  ,  Suzuki, Minoru  ,  Sakurai, Yoshinori  ,  Li, Yanmin  ,  Aoki, Ichio  ,  Takahashi, Hiroyuki  ,  Cabral, Horacio  ,  Nishiyama, Nobuhiro  ,  Kataoka, Kazunori

9 ( 6 )  , pp.5913 - 5921 , 2015-06
Gadolinium (Gd) chelates-loaded nanocarriers have high potential for achieving magnetic resonance imaging (MRI)-guided Gd neutron capture therapy (GdNCT) of tumors. Herein, we developed calcium phosphate micelles hybridized with PEG-polyanion block copolymers, and incorporated with the clinical MRI contrast agent Gd-diethylenetriaminepentaacetic acid (Gd-DTPA/CaP). The Gd-DTPA/CaP were nontoxic to cancer cells at the concentration of 100 μM based on Gd-DTPA, while over 50% of the cancer cells were killed by thermal neutron irradiation at this concentration. Moreover, the Gd-DTPA/CaP showed a dramatically increased accumulation of Gd-DTPA in tumors, leading to the selective contrast enhancement of tumor tissues for precise tumor location by MRI. The enhanced tumor-to-blood distribution ratio of Gd-DTPA/CaP resulted in the effective suppression of tumor growth without loss of body weight, indicating the potential of Gd-DTPA/CaP for safe cancer treatment.

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