会議発表用資料 Brain metabolic correlates of tau accumulation in progressive supranuclear palsy

Furukawa, Shogo  ,  Hirano, Shigeki  ,  Shimada, Hitoshi  ,  Shinotoh, Hitoshi  ,  Sahara, Naruhiko  ,  Endo, Hironobu  ,  Kitamura, Soichiro  ,  Niwa, Fumitoshi  ,  Takahata, Keisuke  ,  Kimura, Yasuyuki  ,  Yamada, Makiko  ,  Ming-Rong, Zhang  ,  Ito, Hiroshi  ,  Higuchi, Makoto  ,  Kuwabara, Satoshi  ,  Suhara, Tetsuya

2015-05-21
内容記述
No.1001193【演題名】Brain metabolic correlates of tau accumulation in progressive supranuclear palsy【演題名(英文)】Brain metabolic correlates of tau accumulation in progressive supranuclear palsy【著者】古川彰吾1,2, 平野茂樹1,2, 島田斉1, 篠遠仁1,3, 佐原成彦1, 遠藤浩信1, 北村総一朗1, 丹羽文俊1, 高畑圭輔1, 木村泰之1, 山田真希子1,4, 張明栄5, 伊藤浩6,7, 樋口真人1, 桑原聡2, 須原哲也1【著者(英文)】Shogo Furukawa1,2, Shigeki Hirano1,2, Hitoshi Shimada1, Hitoshi Shinotoh1,3, Naruhiko Sahara1,Hironobu Endo1, Soichiro Kitamura1, Fumitoshi Niwa1, Keisuke Takahata1, Yasuyuki Kimura1,Makiko Yamada1,4, Ming-rong Zhang5, Hiroshi Ito6,7, Makoto Higuchi1, Satoshi Kuwabara2, TetsuyaSuhara1【所属】1放射線医学総合研究所分子神経イメージング研究プログラム, 2千葉大学大学院医学研究院神経内科学, 3神経内科千葉, 4科学技術振興機構 さきがけ, 5放射線医学総合研究所 分子認識研究プログラム, 6放射線医学総合研究所 先端生体計測研究プログラム, 7福島県立医科大学 先端臨床研究センター【所属(英文)】1Molecular Neuroimaging Program, Molecular Imaging Center, National Institute of Radiological Sciences,2Department of Neurology, Graduate School of Medicine, Chiba University, 3Neurology Chiba Clinic,4Precursory Research for Embryonic Science and Technology, Japan Science and Technology, 5MolecularProbe Program,Molecular Imaging Center, National Institute of Radiological Sciences, 6BiophysicsProgram,Molecular Imaging Center, National Institute of Radiological Sciences, 7Advanced Clinical ResearchCenter, Fukushima Medical UniversityObjectivesTo elucidate brain regions which is associated with cortical tau loads in progressive supranuclear palsy (PSP)patients by [11C]PBB and [18F]FDG PET.Methods:Ten PSP patients [age: 70.2 (8.1),3 females, disease duration 4.6 (3.4) year, mean (SD)] were enrolled in thepresent study. We performed [11C] PBB3 PET and [18F] FDG PET. Cortical tau load was calculated bystandardized uptake value ratio (SUVR) of [11C] PBB3 PET image using the cerebellar cortex as referenceregion. Regional cerebral glucose metabolism was calculated by SUVR of [18F] FDG PET image and wereanalyzed by statistical parametric mapping (spm8) with global normalization. Multiple regression whole brainanalysis was performed with cortical tau load as a covariate. Statistical threshold was determined as P < 0.005uncorrected, extent threshold 160 voxels.Results:Negative correlation between cortical tau load and regional cerebral glucose metabolism was detected in rightanterior thalamus (Zmax = 3.45, voxel size 203).Positive correlation between cortical tau load and regionalcerebral glucose metabolism was found in left paracentral lobule (Zmax = 4.39, voxel size 502) and right inferiorparietal lobe (Zmax = 3.20, voxel size 225).Conclusions:Cortical tau load may explain thalamic dysfunction in PSP patients.
第56回日本神経学会学術大会

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