会議発表用資料 Cell cycle-correlative bystander effects are co-mediated by DNA-PKcs and ATM kinase after high LET carbon ions irradiation

Tu, Wenzhi  ,  Dong, Chen  ,  Konishi, Teruaki  ,  Kobayashi, Alisa  ,  Furusawa, Yoshiya  ,  Uchihori, Yukio  ,  Shao, Chunlin

2015-04-20
内容記述
Radiation-induced bystander effects (RIBE) was demonstrated with accumulated evidence. Recently, several studies have focused on the role of DNA damage and repair in the bystander response, but the heavy ions induced, especially cell cycle-correlative RIBE are still largely unclear. Our present study found that G2/M phase cells had the largest contribution to the RIBE induced by carbon ions irradiation and identified a pivotal role for DNA-PKcs and ATM in this process as two independent factors.
平成26年度放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告会

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