Departmental Bulletin Paper PbSe ナノ粒子を検知できるPeptide-MOF 化学モーターの研究(学内特別研究および国外研修)

池添, 泰弘  ,  Yasuhiro, Ikezoe

We have developed chemical motors composed of metal organic frameworks (MOF) and diphenylalanine (DPA). MOFs are lightweight porous materials which have been studied as promising materials for gas storage or separation , micro reactors, and catalysts. On the other hand, a diphenylalanine is known as a self-assembling small peptide which consists of a critical amino acid sequence for the formation of amyloid fibrils in Alzheimer disease. W hen the MOF -peptide particle is placed on the water surface, it starts moving. This is because the release of DPA molecules from MOF creates the surface tension gradient; the MOF-peptide particle moves toward higher surface tension region. Interestingly , re-crystallization of DPA occurs on the water surface,which enables highly efficient energy conversion from the chemical energy to the kinetic energy.1)W e have also developed a micro power generator which utilizes motion of the MOF -peptide motor and found that the motor is capable of generating electricity large enough to operate micro ele ctronic sensors and devices. 2) In this study, we show novel MOF-peptide motors that sense a certain material; here we report sensing of PbSe nanoparticles. In the experiment, an agarose gel post with PbSe nanoparticles on its top surface was immersed in 1 M urea solution which also includes 1.0 mM EDTA and 2.0 mM NaOH (pH 5.0). In order to observe the chemotactic behavior of the MOF -peptide motor, Pb-binding urease was added in the urea solution. As the urea is decomposed by urease attached to the PbSe nan oparticles, the pH value there increases. Since the DPA dissolves under a high pH condition , surface tension gradient disappears around the PbSe nanoparticles , resulting in termination of the motion of the MOF -peptide motor. In conclusion, this new peptide-MOF motor could sense the location of PbSe nanoparticles. 3)

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