Departmental Bulletin Paper 後腹膜腔への巨大な転移腫瘤を伴った機能性悪性セルトリ細胞腫の犬の 1 例

山本, 昌美  ,  吉村, 久志  ,  木村, 彩友子  ,  市野瀬, 香鈴  ,  神谷, 新司

A male, mixed breed, over 8 years old dog had a mass palpated in the right cryptochidism located at the inguinal subcutaneous region. At necropsy another large mass was observed in the retroperitoneum. The masses in the right testis and in the retroperitoneum were approximately 7.5 cm and 10.0 cm in diameter, respectively.    Histopathological examination revealed that both masses were composed of polygonal cells with moderate to high grade atypia. The tumor cells formed alveolar or cord structures separated by fibrous stroma, and showed a tendency to orient perpendicularly to the basement membrane. Immunohistochemically, the tumor cells were positive for vimentin, inhibin-α and WT1. The testis was diagnosed with malignant Sertoli cell tumor, and the mass in the retroperitoneum was the metastasis from primary testicular tumor. In addition, marked hypoplasia of hematopoietic cells in the bone marrow, squamous metaplasia in the prostate and the gynecomastia were observed. It was suggested that the toxicity of hormones, such as estrogen and others, produced from the functional malignant Sertoli cell tumors was responsible for these lesions.

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