Departmental Bulletin Paper マイクロ波を用いるアニソールのVilsmeier反応

鈴木, 常夫  ,  種村, 潔

Description
4-Methoxybenzaldehyde (3) was obtained by the reaction of anisole (1) with N-methylformanilide (NMFA) and diphosphoryl chloride under maicrowave (MW) irradiation in good yield. On the other hand, by using NMFA and chlorides such as phosphorus oxychloride, thionyl chloride, oxalyl chloride and by using dimethylformamide (DMF) and chlorides such as diphosphoryl chloride, phosphorus oxychloride, thionyl chloride, oxalyl chloride the corresponding aldehyde 3 was obtained in poor yield for the formylation of 1 under MW conditions, respectively. Similarily, by the treatment of anisole (1) with N,N-dimethychloromethyleneiminium chloride under MW irradiation the corresponding aldehyde 3 was obtained in very low yield.
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