Departmental Bulletin Paper The Frequency Variations of the Oxytocin Receptor Gene Polymorphisms among Dog Breeds

27pp.11 - 18 , 2016-03-31麻布大学 , Azabu University
The domestic dog (Canis familiaris) has been diverged from wolves 15,000–100,000 years ago and certain genetic changes may have enabled them to adapt to the human social niche. In this study, we investigated the polymorphisms of the oxytocin receptor gene in dogs and wolves in order to investigate the possibility of the genetic change in the oxytocin system during dog domestication processes. Genotypes of the oxytocin receptor gene polymorphisms were determined in dogs and wolves. The single nucleotide polymorphisms (SNP; rs22927829, rs8679682, rs22896457) were observed in the sampled dogs. On the other hand, for the SNPs rs22927823 and rs22927826, only homozygous GG genotypes were observed (n=25). The frequencies of the SNPs (rs8679682 and rs22896457) were significantly different among wolves and dogs, and also among dog breed groups (p<0.05, chi-square test). The frequency profile of these SNPs among dog breed groups supports the hypothesis that there were selections on the oxytocin receptor gene during the dog domestication processes.

Number of accesses :  

Other information